University of Colorado Cancer Center physician/scientists are among those receiving funding for innovative, groundbreaking projects to advance clinical care for kids with cancer. In its summer grants cycle, the St. Baldrick’s Foundation awarded dozens of grants totaling $23.5 million to support the brightest minds in the field of pediatric cancer research.  Awards from St. Baldrick’s, the largest private funder of childhood cancer research grants, are crucial as federal dollars become harder and harder to obtain.

Adam Green, MD, receives St. Baldrick's Scholar Award

Adam Green, MD, receives St. Baldrick’s Scholar Award

Adam Green, MD, a CU Cancer Center investigator and physician at Children’s Hospital Colorado, received a St. Baldrick’s Scholar Award. He will receive $330,000 over three years to investigate new treatments for aggressive pediatric brain tumors called high-grade glioma and DIPG through lab models and potential clinical trials. Green and his lab discovered a weakness in the tumors and through this funding he hopes to better understand how the tumors grow in order to create a new treatment and hope for better outcomes.

Paul Jedlicka, MD, PhD, receives St. Baldrick's Research Grant

Paul Jedlicka, MD, PhD, receives St. Baldrick’s Research Grant

Paul Jedlicka, MD, PhD, is a CU Cancer Center investigator and pediatric pathologist at Children’s Hospital Colorado. He received a $100,000 St. Baldrick’s Research Grant to understand and target new molecular pathways in high-risk Ewing Sarcoma. Jedlicka’s lab found a new druggable protein involved in gene expression that works abnormally in the disease. His group is working to understand more about how this protein works, what cancer-causing pathways it controls, and how such mechanisms could be blocked to improve patient outcomes.

Amanda Winters, MD, PhD, named St. Baldrick's Fellow

Amanda Winters, MD, PhD, named St. Baldrick’s Fellow

Amanda Winters, MD, PhD, received a St. Baldrick’s Fellow Award. She is clinical fellow in Pediatric Hematology/Oncology at Children’s Colorado.  She is receiving 2 years of funding with the possibility of a third. Winters is testing a new therapy, which is in clinical trials in adult acute myeloid leukemia (AML), to see if it also shows promise against pediatric AML. The drug targets a protein called CD123, which is widely expressed in pediatric and adult AML. In adults, CD123 seems to be a marker for the earliest leukemia cells. If it shows promise in the lab against pediatric AML, Winters would then develop a clinical trial protocol testing the therapy in pediatric patients.

St. Baldrick’s grants are awarded to the following institutions:
• Baylor College of Medicine, Houston, Texas
• Beckman Research Institute of the City of Hope, Duarte, Calif.
• Boston University Medical Campus, Boston, Mass.
• Case Western Reserve University – School of Medicine, Cleveland, Ohio
• Children’s Cancer Therapy Development Institute, Beaverton, Ore.
• Children’s Hospital Boston, Boston, Mass.
• Children’s Hospital Colorado, Aurora, Colo.
• Children’s Hospital Los Angeles, Los Angeles, Calif.
• Children’s Hospital of Philadelphia, Philadelphia, Pa.
• Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, Pa.
• Children’s Oncology Group, Philadelphia, Pa.
• Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
• Columbia University, New York, N.Y.
• Connecticut Children’s Medical Center, Hartford, Conn.
• Dana-Farber Cancer Institute, Boston, Mass.
• Duke University, Durham, N.C.
• Emory University, Atlanta, Ga.
• Fred Hutchinson Cancer Research Center, Seattle, Wash.
• Huntsman Cancer Institute at the University of Utah, Salt Lake City, Utah
• Icahn School of Medicine at Mount Sinai, New York, N.Y.
• Indiana University School of Medicine, Indianapolis, Ind.
• Johns Hopkins University, Baltimore, Md.
• Keck School of Medicine, University of Southern California, Los Angeles, Calif.
• Lucile Packard  Children’s Hospital at Stanford Medicine, Stanford, Calif.
• Memorial Sloan Kettering Cancer Center, New York, N.Y.
• National Cancer Institute, Bethesda, Md.
• Nemours/Alfred I. duPont Hospital for Children, Wilmington, Del.
• New York University School of Medicine, New York, N.Y.
• Oregon Health & Science University, Portland, Ore.
• Penn State College of Medicine, Hershey, Pa.
• Seattle Children’s, Seattle, Wash.
• St. Jude Children’s Research Hospital, Memphis, Tenn.
• Texas A&M University, College Station, Texas
• The Feinstein Institute for Medical Research, Manhasset, N.Y.
• The Research Foundation for The State University of New York on behalf of University at Buffalo, Buffalo, N.Y.
• The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio
• The University of Alabama at Birmingham, Birmingham, Ala.
• The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
• University of Arizona, Tucson, Ariz.
• University of California Davis, Davis, Calif.
• University of California, San Francisco, San Francisco, Calif.
• University of California, Santa Cruz, Santa Cruz, Calif.
• University of Chicago Medicine, Chicago, Ill.
• University of Colorado Denver, Aurora, Colo.
• University of Kentucky, Lexington, Ky.
• University of Michigan, Ann Arbor, Mich.
• University of Nebraska Medical Center, Omaha, Neb.
• University of Pennsylvania, Philadelphia, Pa.
• University of Rochester, Rochester, N.Y.
• University of Texas Health Science Center at San Antonio, San Antonio, Texas
• University of Virginia, Charlottesville, Va.
• University of Wisconsin School of Medicine and Public Health, Madison, Wisc.
• UT Southwestern Medical Center, Dallas, Texas
• Van Andel Research Institute, Grand Rapids, Mich.
• Wayne State University, Detroit, Mich.
• Yale School of Medicine, New Haven, Conn.